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pentobarbital will reduce the level or effect of lorlatinib by influencing hepatic/intestinal enzyme CYP3A4 metabolism.pentobarbital will lower the extent or outcome of artemether/lumefantrine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Stay clear of or Use Alternate Drug. Coadministration with strong CYP3A4 inducers can result in low